Bladder Cancer   

Questions discussed in this category



No actionable mutation on NGS testing. What approved therapy do you prefer? Are there specific investigational agents currently in clinical trial...

Do you prefer surgery vs radiation? For surgical patients, do you offer neoadjuvant chemotherapy? If so what regimen? 

Is there a role for neoadjuvant cisplatin-based chemotherapy? Do patients with sarcomatoid histology respond to checkpoint inhibitors?

Would you forego neoadjuvant chemotherapy? Are you using growth factor support differently? Any changes to immunotherapy? Other considerations?

Would you treat with chemoimmunotherapy based on IMvigor130 data presented at ESMO Congress 2019?

e.g. lymph node metastasis, presence of tumor involving the peritoneal surfaces and/or the abdominal wall. If so, which regimen would you offer?

Patient has small cell carcinoma of the bladder with extensive hepatic metastases. Would you extrapolate the approach from IMpower133?

There are now five PD-1/PDL-1 inhibitors approved for metastatic bladder CA, one (Atezolizumab) as first-line therapy in cisplatin-ineligible patients...

What systemic therapy do you use? Do you incorporate any multi-modality therapies?

The current treatment for bladder adenoCA is surgery. However in non-surgical candidates, RT is an option. Would you consider adding chemo ? Also woul...

Would you offer it for positive margins? NCCN says to consider adjuvant radiation for pT3-T4 or pN0-2. Is there sufficient evidence for adjuvant radia...

If so, is there a role for IMRT?  I was taught to use the RTOG style ports with whole pelvis 4 field box and then boost field to entire bladder ...

For a patient with a history of non-muscle invasive disease in the bladder, presenting with a prostatic urethra only recurrence, do you approach this ...

In the IMvigor 210 trial, increased PD-L1 expression in patients’ tumors was associated with response to atezolizumab, but some patients whose t...

Since the benefit of neoadjuvant chemotherapy is well-defined in muscle-invasive bladder cancer, is it reasonable to consider this in upper-tract tumo...

I've heard justification for treating the whole bladder to 60-64 Gy based on the UK MRC study (James et al. NEJM 2012 and Huddart et al. IJROBP 2013) ...

Realistically, there will always be some (hopefully small) inconsistency with bladder filling, and thus some small bowel could easily receive &ge...

Assuming a patient who could tolerate either, which is preferred? Does this depend on the choice for concurrent chemotherapy (5FU+mitomycin vs ci...

Specifically, for high grade T1 bladder cancer, is there evidence that definitive radiation yields similar control rates compared to cystectomy?

In the definitive setting, and would that change if cystecomy was planned if there was a complete response after CRT?  (similar to TCC paradigm).


Papers discussed in this category


N. Engl. J. Med., 2012-04-19

Practical radiation oncology, 2015

Int. J. Radiat. Oncol. Biol. Phys., 2012-03-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-07-01

Int. J. Radiat. Oncol. Biol. Phys., 2004-05-01

International journal of radiation oncology, biology, physics, 1990-09

Radiother Oncol, 2006 Oct

European urology, 2012-04

European urology, 2014-07

J. Urol., 2007-09-01

J. Clin. Oncol., 2006-05-20

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-07-10

Lancet (London, England), 2017-01-07

The New England journal of medicine, 2017-03-16

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-10

Bladder cancer (Amsterdam, Netherlands), 2017-01-27

International journal of radiation oncology, biology, physics, 2016-09-01

International journal of radiation oncology, biology, physics, 2016-04-01

International journal of radiation oncology, biology, physics, 2017-03-15

International journal of radiation oncology, biology, physics, 2013-02-01

Cancer, 2014-04-15

J Clin Oncol, 2011 Jun 1

Med Dosim, 2015 Winter

International journal of radiation oncology, biology, physics, 2016-06-01

World J Urol, 2015-11-01

Int. J. Radiat. Oncol. Biol. Phys., 2014-08-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-06-10

Nature, 2013-07-11

The New England journal of medicine, 2015-10-29

J Clin Oncol, 2016 Feb 29

J Clin Oncol, 2020 Sep 11

Clinical cancer research : an official journal of the American Association for Cancer Research, 2019-01-01

Urology, 2007-02

Case Rep Urol, 2013 May 08

The New England journal of medicine, 2003-08-28

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-06-20

Lancet,

JAMA Oncol, 2018 Nov 1

The Lancet. Oncology, 2017-11

Ann. Oncol.,

J. Clin. Oncol., 2011 Dec 12

Eur. Urol., 2016 Mar 17

Eur Urol Oncol, 2019 Oct 08

Eur. Urol., 2019 Sep 26

Eur. Urol., 2020 Jan 17

Lancet, 2020 Mar 05

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-08-01

Lancet Oncol., 2014 Dec 11

BJU international, 2011-09

European urology, 2013-08

Cancer,

Nature genetics, 2016-04

J. Urol., 2012 Nov 15

Arthritis and rheumatism, 2010-01

J. Rheumatol., 2019 Sep 01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-10-10

N Engl J Med,