Neuro-critical care   

In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.

With reference to recent MIND and ENRICH trials.

Especially in the setting of SAH/ICH with intermittent fevers

Would you ever obtain both?

Considering the short half-life, at what point would it be deemed too late to administer any reversal agent, and to consider withholding it?

When would you consider using anticoagulation and for how long?

Have recent trials (TRAIN trial and HEMOTION trial) influenced your approach? 

Blood pressure targets for ischemic stroke and intracerebral hemorrhage are described in several guidelines. However, in patients with acute stroke wh...

If so, what is the typical duration?

For example, in the setting of TBI, how do you guide the duration of the medical treatment?

Is there management guidance on when to start after stroke onset?

Individual times in the therapeutic range while on VKA treatment was not registered in FRAIL-AF.

In light of the evidence associating cerebral amyloid angiopathy (CAA) with subdural hemorrhage; Rivier et al., PMID 38147345.

In the span between the HACA trial and the Targeted Temperature Management in Out-of-Hospital Cardiac Arrest study (Dankiewicz et al., PMID 34133859),...

What are the sources for this and are they reliable by today’s standards? Numerous case series report various abnormal movements but how reliabl...

E.g., a patient has an intracranial hemorrhage after TBI with convulsive status epilepticus.

Plasmapheresis first or IVIG first in GBS? What other treatment options are there for severe disabling GBS?

In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients. 

Given the risk of elevated ICP, would you attempt a brain MRI to further characterize the lesion? Or would CT imaging suffice prior to intervention?

For patients who are unable to have complete brain stem testing, would you recommend apnea testing prior to ancillary tests in case of suspected brain...

For instance, if the patient doesn’t tolerate apnea testing, is too unstable to go for ancillary testing outside the ICU, and TCDs/EEG are unava...

What modality do you prefer?

What is the cost and accessibility of CYP2C19 gene testing? Does the limited availability of rapid genotyping techniques limit the clinical applicabil...

How do you plan to incorporate the results of the CHANCE-2 trial (Wang et al., PMID 34708996) in your own practice?

What factors influence your thinking?

Is there any benefit to starting hyperosmolar therapy prior to the development of depressed level of consciousness or midline shift?

What modality do you prefer?