Radiation Oncology   

Questions discussed in this category

Would you consider empiric SRS if biopsy/resection is not feasible? When would you consider liquid biopsy?

If so, how long do you continue medication and when do you discontinue? Does treatment with surgical resection versus radiation alone change your man...

For example a 1 or 2 mm brain metastasis? Would you consider waiting for these to enlarge slightly for reasons such as more certainty they are real, l...

What is your preferred dose/fractionation following a previous course of radiotherapy?

Assouline et al., PMID 24411632 recommend delivering 500cGy x 4 fractions = 2000cGy on days 1, 3, 8, 10. Do you follow this schedule, treat every othe...

 If not, then what is your preferred treatment and would you integrate SRS into it? 

Do you ever add prophylactic Keppra (levetiracetam) for glioblastoma patients without a seizure history based on data such as this study ( ...

If so, what percent likelihood do you quote patients for this risk with SRS, SRT and fully fractionated therapy?

Do you routinely discontinue the device or continue if they are otherwise tolerating the treatment well? 

Do you require neurosurgical evaluation first? Do you require any patients to wear a neck brace?  

For stroke-like migraine attacks after radiation therapy (SMART syndrome), does your management of these patient's change with recurrent episodes? How...

Is there any additional benefit to radiation in addition to steroids in a patient who is not a surgical candidate?

Has the recently published interim analysis of the CATNON trial altered your utilization of temozolomide? Does IDH status change your treatment appro...

Do you consider the small, but statistically significant, improvement in OS to outweigh the side effects of treatment?

What factors play into your decision whether to re-treat the brain with craniospinal radiotherapy vs irradiation of the spine only vs other measures (...

E.g. The case in question is for a patient planned for thoracic RT for LS-SCLC. Any medications that may help or just give much bigger expansions to c...

When do you favor RT? What is your preferred dose/fractionation?

How does length of time from prior chemoradiotherapy influence your management?

In a palliative setting, how long would you wait to initiate WBRT?

Papers discussed in this category

Stroke, 2008 Jul 17

J Neuroimaging, 2020 Feb 10


International journal of radiation oncology, biology, physics, 2018-03-15

J Clin Oncol, 2021 Dec 13

J Clin Oncol, 2020 Jul 24

Pract Radiat Oncol, 2022 Sep-Oct

Lancet Oncol, 2016 Sep 27

Neuro Oncol, 2021 May 05

Radiother Oncol, 2021 May 06

The New England journal of medicine, 2014-02-20

The New England journal of medicine, 2014-02-20

Neuro-oncology, 2016-09

Onco Targets Ther, 2017 Jan 18

Journal of neurosurgery, 2005-09

Surgical neurology, 2000-05

Cureus, 2020 Jun 11

Stereotact Funct Neurosurg, 2019 Nov 26

N Engl J Med,

Acta Oncol, 2015 Oct 23

Int J Radiat Oncol Biol Phys, 2020 Jun 13

Neuro-oncology, 2013-10

J. Clin. Oncol., 2020 Feb 14

Cancer, 2020 May 19

Acta Neurochir (Wien), 2019 Jan 29

N Engl J Med,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-09-01

Lancet Oncol, 2021 May 14

Strahlenther Onkol,

J Clin Oncol, 2012 Oct 15

International journal of radiation oncology, biology, physics, 2018-06-01

Surgical neurology international, 2018

J Neurooncol, 2019 Oct 01

Progress in neurological surgery, 2013


Journal of neurosurgery. Spine, 2010-09

Spine, 2010-10-15


Cancer, 2011 Feb 01

JAMA, 2017-12-19

Cancer, 2012-02-15

Neurosurgery, 2010-11

Neurosurgery, 2008-01

Neurosurgery, 2009-01

J Neurooncol, 2013 Nov

Neurosurgery, 2016-07

World neurosurgery, 2016-07

Strahlenther Onkol, 2017 Jun 15

World Neurosurg, 2016-03-01

J. Neurosurg., 2016-12-01

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017-12

Neurosurgery, 2018-06-01

Journal of radiosurgery and SBRT, 2013

Int. J. Radiat. Oncol. Biol. Phys., 2019 Nov 29

J Natl Compr Canc Netw, 2020 Nov 2

Radiat Oncol, 2021 Feb 17

Neuro Oncol,

J Neurosurg,

World Neurosurg, 2017 Mar 12

World Neurosurg,

The New England journal of medicine, 2018-08-23

Lancet Oncol, 2020 Apr 03

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-03-01

Sci Rep, 2020 Jul 01

Neuro Oncol,

N Engl J Med,

The Laryngoscope, 2016-01

Journal of the neurological sciences, 2011-09-15

Journal of neuro-oncology, 2012-01

The New England journal of medicine, 2005-03-10

Journal of neurosurgery, 2018-01

Journal of neurosurgery, 2013-04

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-05-01

Cochrane Database Syst Rev, 2020 Apr 28