Pediatric Hematology/Oncology

Drug Toxicity

Questions discussed in this category

Do you use prophylactic defibrotide in pediatric patients undergoing BMT who are considered to be at high risk for the development of VOD/SOS?

What features make a patient high-risk?

2 Answers available

For what patients/diagnoses do you currently use sodium thiosulfate to reduce the risk of cisplatin associated ototoxicity?

STS was approved in 2022 in the US to reduce risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localiz...

1 Answer available

What, if any, cardioprotective measures beyond dexrazoxane may be used to minimize cardiac risk during or after chemo- or radio-therapy?

Are there other measures, pharmocologic or adjunctive, that can be used or are under investigation to mitigate cardiotoxicity related to chemo- or rad...

2 Answers available

Papers discussed in this category

Eur Heart J, 2022 Nov 01

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).

JACC. Heart failure, 2022 Jun 08

Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes Among Patients Treated With Anthracyclines.

JAMA, 2023 Aug 8

Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial.

Cardio-oncology (London, England), 2021 Sep 27

Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial.

JACC. CardioOncology, 2023 Jun 20

Cardioprotection in Patients at High Risk of Anthracycline-Induced Cardiotoxicity: Primer.

Cancer medicine, 2018-05-30

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials.

Pediatric blood & cancer, 2023 Feb 11

Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it.

Journal of cancer survivorship : research and practice, 2023 Jan 13

Special considerations in the design and implementation of pediatric otoprotection trials.

Pediatric blood & cancer, 2024 Nov 01

The benefits of prophylactic defibrotide: Are the tides turning?

Bone marrow transplantation, 2020 Aug 24

Efficacy of low dose and short duration defibrotide prophylaxis for hepatic veno-occlusive disease after autologous haematopoietic stem cell transplantation.

Journal of clinical medicine, 2024 Nov 17

Hepatic Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease (SOS/VOD) Primary Prophylaxis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Network Meta-Analysis of Randomized Controlled Trials.

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