Pediatric Oncology

AYA Tumor Board

Questions discussed in this category

Is there any scenario where you would consider treating a relapsed AYA patient with Hodgkin Lymphoma without consolidative auto transplant?

If so, what treatment regimen would you recommend?

1 Answer available

Should high-dose methotrexate be used in the treatment of AYA patients with osteosarcoma?

2 Answers available

In light of the recent rEECur trial interim analysis, would you offer high-dose ifosfamide to an AYA patient with relapsed Ewing's sarcoma who initially had a complete response to up-front therapy?

J Clin Oncol 40, 2022 (suppl 17; abstr LBA2). https://meetings.asco.org/abstracts-presentations/209024

2 Answers available

What is your first line of therapy for refractory Hodgkin lymphoma in an AYA patient?

1 Answer available

How would you manage asymptomatic brain metastases from testicular non-seminomatous germ cell tumor with a choriocarcinomatous component?

2 Answers available

What is the preferred regimen for AYA patients with T-Cell Lymphoblastic Lymphoma?

1 Answer available

How would you treat stage II pediatric type follicular lymphoma that is not amenable to surgical resection in an adolescent and young adult patient?

1 Answer available

What dose of PEG-asparaginase do you recommend for teens with high BMI treated on a pediatric ALL regimen?

Would you plan straight pediatric dosing using 2500 Units/m2 or a cap of 3750 Units as used in some adult ALL regimens due to excess liver/pancreas to...

2 Answers available

Should a teenager diagnosed with CML in blast crisis go to transplant once MRD is negative?

2 Answers available

What treatment regimen would you recommend for young adults with platinum refractory relapsed germ cell tumors?

2 Answers available

Would you recommend hematopoietic stem cell transplant for AYAs with Ph-like ALL?

1 Answer available

What is the preferred treatment approach for an AYA patient with intermediate to high risk Hodgkin lymphoma: The pediatric approach (ABVE-PC +/- radiation) or the adult approach (ABVD with possible escalation to BEACOPP)?

1 Answer available

What is your approach for salvage therapy in a patient with Relapsed/Refractory Primary Mediastinal B-Cell Lymphoma that has received a Rituximab-containing upfront regimen?

1 Answer available

Should end-of-therapy echocardiograms be obtained for AYA patients with sarcomas who have received high-dose anthracyclines?

At what frequency and for how long should echos be monitored?

1 Answer available

Is dexrazoxane recommended for cardioprotection in AYA patients with Hodgkin lymphoma who are receiving anthracyclines as part of their upfront therapy?

3 Answers available

Can an AYA patient with newly diagnosed AML safely sperm bank after starting cytoreduction with hydroxyurea or cytarabine?

2 Answers available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-08-20

Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group.

J Clin Oncol, 2020 Apr 28

Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in Patients With Acute Myeloid Leukemia: A Report From the Children's Oncology Group.

Blood, 2009-09-03

A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425.

J Clin Oncol, 2019 Oct 14

Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.

Journal of the National Comprehensive Cancer Network : JNCCN, 2018-01

Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Cancer medicine, 2019-01

Safety and efficacy of high-dose methotrexate for osteosarcoma in adolescents compared with young adults.

Journal of the National Cancer Institute, 1988-07-06

The role of methotrexate in osteosarcoma.

Annals of oncology : official journal of the European Society for Medical Oncology, 2015-02

EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.

Anticancer Drugs,

Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.

J Adolesc Young Adult Oncol, 2019 Nov 08

Methotrexate-Etoposide-Ifosfamide Compared with Doxorubicin-Cisplatin-Ifosfamide Chemotherapy in Osteosarcoma Treatment, Patients Aged 18-25 Years.

N. Engl. J. Med., 2018-01-25

Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma.

Biol. Blood Marrow Transplant., 2019 Aug 22

Hematopoietic Cell Transplantation in the Treatment of Adult Acute Lymphoblastic Leukemia: Updated 2019 Evidence-Based Review from the American Society for Transplantation and Cellular Therapy.

Bone Marrow Transplant, 2018 Nov 01

Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).

Biol Blood Marrow Transplant, 2019 Aug 21

Hematopoietic Cell Transplant Consideration for Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia Patients.

J Clin Oncol,

Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease.

Ann Oncol, 2007 Nov 15

Combination chemotherapy with gemcitabine, oxaliplatin, and paclitaxel in patients with cisplatin-refractory or multiply relapsed germ-cell tumors: a study of the German Testicular Cancer Study Group.

Biol Blood Marrow Transplant, 2019 Jul 01

Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party.

Ann Hematol, 2015 Mar 27

Management of chronic myeloid leukemia in blast crisis.

Leukemia, 2008-12

Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase.

Leuk Lymphoma, 2019 Nov 04

Efficacy and toxicity of reduced vs. standard dose pegylated asparaginase in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.

Zhonghua Bing Li Xue Za Zhi,

[Clinicopathological characteristics of pediatric-type follicular lymphomas: an analysis of 37 cases].

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-02-01

Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options--An Analysis From the Global Germ Cell Cancer Group.

Cancer, 2020 Mar 15

High-dose chemotherapy plus peripheral blood stem cell transplantation for patients with relapsed germ cell tumors and active brain metastases.

J Clin Oncol, 2021 Apr 06

Predicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.

British journal of haematology, 2014-06

F-18 FDG-PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma.

International journal of radiation oncology, biology, physics, 2019-06-01

Patterns of Failure and Survival Outcomes after Total Lymphoid Irradiation and High-Dose Chemotherapy with Autologous Stem Cell Transplantation for Relapsed or Refractory Classical Hodgkin Lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology, 2007-04

Phase I/II trial of total lymphoid irradiation and high-dose chemotherapy with autologous stem-cell transplantation for relapsed and refractory Hodgkin's lymphoma.

Blood, 2018-07-05

Brentuximab vedotin plus bendamustine: a highly active first salvage regimen for relapsed or refractory Hodgkin lymphoma.

Blood,

Getting to transplant in Hodgkin lymphoma: BVB.

Blood,

Response-adapted anti-PD-1-based salvage therapy for Hodgkin lymphoma with nivolumab alone or in combination with ICE.

J Clin Oncol, 2021 Jun 25

Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma.

Pediatr Blood Cancer, 2022 Oct 02

Irinotecan dose schedule for the treatment of Ewing sarcoma.

Clin Cancer Res, 2023 Jan 09

Longer versus shorter schedules of vincristine, irinotecan and temozolomide (VIT) for relapsed or refractory Ewing sarcoma: a randomized controlled phase 2 trial.

Journal of the National Comprehensive Cancer Network : JNCCN, 2012-05

Hodgkin lymphoma, version 2.2012 featured updates to the NCCN guidelines.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-09-15

Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy.

Cancer, 2010-09-15

Initial response to salvage therapy determines prognosis in relapsed pediatric Hodgkin lymphoma patients.

Pediatric blood & cancer, 2006-03

APE chemotherapy for children with relapsed Hodgkin disease: a Pediatric Oncology Group trial.

Pediatric blood & cancer, 2014-04

Stratification of treatment intensity in relapsed pediatric Hodgkin lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-03-20

Phase II study of weekly gemcitabine and vinorelbine for children with recurrent or refractory Hodgkin's disease: a children's oncology group report.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001-05-01

Outcomes of treatment of children and adolescents with recurrent non-Hodgkin's lymphoma and Hodgkin's disease with dexamethasone, etoposide, cisplatin, cytarabine, and l-asparaginase, maintenance chemotherapy, and transplantation: Children's Cancer Group Study CCG-5912.

Annals of oncology : official journal of the European Society for Medical Oncology, 2011-02

Efficacy of high-dose methotrexate, ifosfamide, etoposide and dexamethasone salvage therapy for recurrent or refractory childhood malignant lymphoma.

Pediatric blood & cancer, 2015-01

Ifosfamide and vinorelbine is an effective reinduction regimen in children with refractory/relapsed Hodgkin lymphoma, AHOD00P1: a children's oncology group report.

The Lancet. Oncology, 2018-09

Brentuximab vedotin with gemcitabine for paediatric and young adult patients with relapsed or refractory Hodgkin's lymphoma (AHOD1221): a Children's Oncology Group, multicentre single-arm, phase 1-2 trial.

N Engl J Med, 2022 Nov 03

Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.

Lancet, 1993 Apr 24

Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial.

Lancet, 2002 Jun 15

Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial.

Crit Rev Oncol Hematol, 2014 May 02

High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed or refractory Hodgkin lymphoma: a systematic review with meta-analysis.

Br J Haematol, 2014 Feb 07

Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy.

Blood, 2023 Apr 27

Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults.

J Clin Oncol, 2005 Sep 01

Salvage therapy of progressive and recurrent Hodgkin's disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group.

J Pediatr Hematol Oncol, 2004 Nov

Outcome after autologous hemopoietic stem cell transplantation in relapsed or refractory childhood Hodgkin disease.

Hemasphere, 2020 Jan 10

Risk and Response Adapted Treatment Guidelines for Managing First Relapsed and Refractory Classical Hodgkin Lymphoma in Children and Young People. Recommendations from the EuroNet Pediatric Hodgkin Lymphoma Group.

J Pediatr Hematol Oncol, 2001 Jan

Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a children's cancer group report.

Br J Cancer, 1992 Dec

Outcome of children with resistant and relapsed Hodgkin's disease.

Int J Radiat Oncol Biol Phys, 2001 Dec 01

Response-adapted radiotherapy in the treatment of pediatric Hodgkin's disease: an interim report at 5 years of the German GPOH-HD 95 trial.

J Clin Oncol, 2007 Apr 09

Outcome of patients experiencing progression or relapse after primary treatment with two cycles of chemotherapy and radiotherapy for early-stage favorable Hodgkin's lymphoma.

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