General Internal Medicine
Questions discussed in this category
Is there an absolute cutoff for AST/ALT that you use where the risks outweigh the potential harm reduction benefits of using the medication? &nbs...
How do you weigh cardiovascular risks against the potential functional and emotional consequences of undertreated ADHD? What blood pressure thresholds...
Related Q&A on antipsychotics in Alzheimer's.In light of the publication from Choma et al., PMID 41063545.
Are there any special concerns for antipsychotics with a higher anticholinergic burden?
I.e. no sleep disorder diagnosis, unsuccessful behavioral interventions for improved sleep
For your recommended medication, are you doing a scheduled set dose, or is it primarily symptom-driven?
Do you use different approaches in different settings (i.e., the ED vs. outpatient clinic)? Do you use different approaches for chronic vs acute suici...
How do you approach shared decision-making when patients express hesitancy about medication exposure in utero? What is your approach when a patient is...
In what patient populations would you consider using disulfiram (Antabuse) instead of, or in addition to, acamprosate or naltrexone? In your experienc...
How do you educate patients about the role exercise may play in depression treatment? What type, frequency, and intensity of exercise do you recommend...
How do you critically assess the evidence base for functional medicine approaches? How do you respond when patients specifically request functional me...
Assume QTc is not prolonged, electrolytes are reasonably normal, and the patient is not already on heavy psychotropic polypharmacy.
Do you avoid certain antidepressants related to the risks on suppressing respiratory-drive which is potentially concerning in patients with high cord ...
Would you consider the risk of masking autonomic signs of alcohol withdrawal with clonidine different from beta-blockers?
Which genetic/other testing should be considered in an early-onset dementia work-up?
Should one restart lamotrigine or look for an alternative? If no other alternative available, is slow titration vs regular titration preferred?
What testing do you typically proceed with?
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Papers discussed in this category
JAMA network open, 2022 Dec 01
International journal of antimicrobial agents, 2023 Jun 08
Pharmacy (Basel, Switzerland), 2023 Nov 20
International journal of antimicrobial agents, 2023 May 07
J Acad Consult Liaison Psychiatry, 2023 Nov-Dec
Case reports in nephrology and dialysis, 2021 Aug 04
The primary care companion for CNS disorders, 2022 Dec 08
Transplantation direct, 2023 Jul 12
Alcohol (Fayetteville, N.Y.), 2014-06
Neurology, 1991 Mar
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2013 Aug 31
The European respiratory journal, 2020 Apr 21
Journal of sleep research, 2023 Jul 05
Expert opinion on pharmacotherapy, 2023 Jun 27
The American journal of psychiatry, 2010-06
Depression and anxiety, 2013-06
Journal of addiction medicine, 2021 May-Jun 01
The American journal on addictions, 2023 Mar 20
Drug and alcohol dependence, 2024 Sep 07
JAMA psychiatry, 2025 Apr 01
Journal of addiction medicine, 2020 May/Jun
American journal of preventive medicine, 2015-10
JHEP reports : innovation in hepatology, 2024 Apr 10
The Cochrane database of systematic reviews, 2006-07-19
Psychiatry and clinical neurosciences, 2010 Feb 01
Basic & clinical pharmacology & toxicology, 2023 Jun 20
Ochsner journal, 2013 Winter
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2013-06
Case reports in cardiology, 2016
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2016 May-Jun
Headache, 2005 Feb
Neurology, 2004 May 25
The Cochrane database of systematic reviews, 2014-03-21
Translational psychiatry, 2022 Apr 01
Journal of sleep research, 2020 Dec 02
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2016 Jan 27
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022 Dec 01
CNS drugs, 2024 Aug 09
PM & R : the journal of injury, function, and rehabilitation, 2022 Jan 12