Male Breast Cancer

Questions discussed in this category

How would you treat a newly diagnosed male with metastatic HR+ breast cancer?

Do you give first-line CDK 4/6 inhibitors with Tamoxifen or Aromatase Inhibitor (+/- GnRH analog)?

1 Answer available

What is your approach to adjuvant endocrine therapy in hormone receptor positive male breast cancers?

Is there any role for AI + OS? What duration of therapy do you recommend?

2 Answers available

Would you utilize OncotypeDX to guide decision making for a male with ER+ HER2- breast cancer and 1-3 positive sentinel lymph nodes?

3 Answers available

Would you treat a male breast cancer patient with post-mastectomy radiotherapy for a single positive sentinel lymph node and a low Oncotype?

1 Answer available

How would you approach treatment for a HR+ HER2+ clinical T1c N0 male breast cancer?

3 Answers available

Is it reasonable to use hypofractionation in early stage male breast cancer s/p lumpectomy?

What clinical and pathologic features - if any - would necessitate conventional fractionation?

1 Answer available

Would you offer a male patient adjuvant radiation for treatment of his breast cancer if his axillary dissection specimen shows a single node with isolated tumor cell(s) (ITC)?

The treatment of ITC and micrometastases in lymph nodes in women with breast cancer is controversial. Given the rarity of male breast cancer, complex ...

1 Answer available

What adjuvant endocrine therapy would you recommend for a male patient with HR positive breast cancer and history of DVT/PE?

1 Answer available

Do you use Oncotype to determine the benefit of adjuvant chemotherapy in a male patient with breast cancer?

Do you consider it only in lymph-node negative or up to three lymph nodes?

2 Answers available

Would you recommend PMRT in a male patient with a T2N0 breast cancer?

1 Answer available

What is your approach to pre-menopausal or male breast cancer patients on adjuvant tamoxifen who develop a DVT, in the absence of other risk factors for thromboembolic disease?

1 Answer available

What is the preferred agent for metastatic male breast cancer patient who progresses on tamoxifen and is not a candidate for chemotherapy?

2 Answers available

Would you consider omitting breast radiation in a male with early stage breast cancer who has undergone BCT?

If a male has early stage breast cancer and would otherwise meet criteria for the CALGB or PRIME II trials, would omission of radiation be an option? ...

1 Answer available

Papers discussed in this category

Breast Cancer Res. Treat., 2013-01-01

Adjuvant therapy with tamoxifen compared to aromatase inhibitors for 257 male breast cancer patients.

J Clin Oncol, 2020 Feb 14

Management of Male Breast Cancer: ASCO Guideline.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010-04-20

Multidisciplinary meeting on male breast cancer: summary and research recommendations.

National Cancer Institute (US),

PDQ Cancer Information Summaries

J Hematol Oncol, 2015 May 17

Role of gonadotropin-releasing hormone analogues in metastatic male breast cancer: results from a pooled analysis.

Breast Cancer Res. Treat., 2015 Apr 08

Aromatase inhibitors in male breast cancer: a pooled analysis.

International journal of radiation oncology, biology, physics, 2017-06-01

Postmastectomy Radiation Therapy Is Associated With Improved Survival in Node-Positive Male Breast Cancer: A Population Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-05-10

Molecular Characterization and Mortality From Breast Cancer in Men.

Mol Clin Oncol, 2019 Nov 29

Male patient with metastatic stage IV breast cancer achieves complete remission on second line Abemaciclib, Fulvestrant and Leuprolide: A case report.

Clin. Cancer Res., 2019 Oct 24

FDA Approval Summary: Palbociclib for Male Patients with Metastatic Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-08-01

Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Annals of oncology : official journal of the European Society for Medical Oncology, 2012-06

Retrospective review of male breast cancer patients: analysis of tamoxifen-related side-effects.

Br J Cancer, 2019 Jan 17

Tamoxifen treatment for male breast cancer and risk of thromboembolism: prospective cohort analysis.

American journal of clinical oncology, 2016-10

Radiotherapy and Male Breast Cancer: A Population-based Registry Analysis.

Journal of the American College of Surgeons, 2008-04

Sentinel lymph node biopsy is successful and accurate in male breast carcinoma.

Annals of surgical oncology, 2013-05

Outcomes of partial mastectomy in male breast cancer patients: analysis of SEER, 1983-2009.

Clinical breast cancer, 2016-04

Is Breast Conserving Therapy a Safe Modality for Early-Stage Male Breast Cancer?

Oncology (Williston Park), 2021 Aug 13

A 64-Year-Old Man With Germline BRCA2-Mutated Breast Cancer: Known and Unknown Aspects of Male Breast Cancer.

Eur J Cancer, 2016 Dec 08

Locoregional treatment and overall survival of men with T1a,b,cN0M0 breast cancer: A population-based study.

Oncologist,

Sentinel lymph node biopsy in male patients with early breast cancer.

JAMA, 2011-02-09

Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial.

Lancet Oncol., 2014-11-01

Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial.

N Engl J Med, 2021 Dec 01

21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer.

Clin Cancer Res, 2019 Nov 20

Sex Disparity Observed for Oncotype DX Breast Recurrence Score in Predicting Mortality Among Patients with Early Stage ER-Positive Breast Cancer.

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