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Medical Oncology

Thymoma and Thymic Carcinoma   

Questions discussed in this category

For the neoadjuvant treatment for thymoma, when do you favor CAP with prednisone over CAP?
CAP with prednisone: Kim et al., PMID 15140551
1 Answer available
How does metaplastic thymoma histology impact your decision regarding adjuvant radiation?
E.g. would it prompt you to offer adjuvant RT in Masaoka IIA? Does the histology have a different prognosis?
1 Answer available
What second line therapy do you use for metastatic thymoma that recurs following CAP?
3 Answers available
For patients with metastatic thymic carcinoma, is there a role for local treatment options such as SBRT for oligoprogressive or oligopersistent disease after systemic therapy?
1 Answer available
How would you treat patient with a recurrent thymic carcinoma after prior surgery and concurrent chemoradiation?
Chemoradiation completed 1.5 years prior
1 Answer available
When do you add chemotherapy to post-operative RT for thymomas after a R2 resection?
1 Answer available
Is there a role for checkpoint inhibition in patients with advanced, high PD-L1 expressing, chemotherapy-refractory thymoma?
What if the patient has thymoma-associated myasthenia gravis?
1 Answer available
When do you consider preoperative chemoRT v. chemotherapy in unresectable thymoma or thymic carcinoma?
The current NCCN guidelines reserves radiation for patients who are not resectable after induction chemotherapy. Does it make sense to offer concurren...
1 Answer available
What factors other than resection status (R1,2) do you consider when offering adjuvant chemotherapy for patients with thymic carcinoma, and how do you coordinate with post-op radiation?
1 Answer available


Papers discussed in this category

J. Clin. Oncol., 2018 Jun 15
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial.
The Lancet. Oncology, 2015-02
Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial.
J. Clin. Oncol., 2017 Dec 14
Phase II Study of Everolimus in Patients With Thymoma and Thymic Carcinoma Previously Treated With Cisplatin-Based Chemotherapy.
J. Thorac. Cardiovasc. Surg.,
Prognostic factors and long-term results after thymoma resection: a series of 307 patients.
Cancer, 2015 Jan 06
Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: the Japanese Association for Research on the Thymus Database Study.
Eur J Cardiothorac Surg,
Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours.
Lancet Oncol.,
Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2019 Oct 22
Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions.

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