MGUS

Questions discussed in this category

What is your treatment approach for MAG antibody associated polyneuropathy?

If using rituximab, how often are you treating the patient? E.g., every 6 months or alternatively, do you use a serological test like B cell number, M...

1 Answer available

When MGUS is suspected in a patient with one risk factor and no evidence of end-organ damage, what additional workup should be done, if any?

Risk factors include: non-IgG subtype, abnormal serum light chain ratio, M-protein >=1.5 mg/dL. Further work up could include imaging, bone marrow...

1 Answer available

What is your clinical threshold for treating a potential monoclonal gammopathy of thrombotic significance?

New data suggests monoclonal gammopathies can be associated with thrombotic events. Is your practice changing to include monoclonal gammopathy evaluat...

1 Answer available

Does receiving IVIG confound the result of SPEP and/or UPEP?

2 Answers available

What is your threshold to diagnose light chain MGUS with only a slight elevation in the light chain ratio, in a patient without other CRAB symptoms and no M spike?

When would you consider a bone marrow biopsy?

4 Answers available

Do you check beta 2 microglobulin in patients with MGUS?

Does it assist in prognosis in any way?

1 Answer available

Do you recommend IVIg and/or cytoreduction for patients with IgM MGUS with reciprocal depression in IgG and recurrent infections?

Infection is not part of the criteria for starting treatment both in UpToDate and in NCCN guidelines.

1 Answer available