Neuro-critical care   

Questions discussed in this category



Is there management guidance on when to start after stroke onset?

Blood pressure targets for ischemic stroke and intracerebral hemorrhage are described in several guidelines. However, in patients with acute stroke wh...

In light of the evidence associating cerebral amyloid angiopathy (CAA) with subdural hemorrhage; Rivier et al., PMID 38147345.

In the span between the HACA trial and the Targeted Temperature Management in Out-of-Hospital Cardiac Arrest study (Dankiewicz et al., PMID 34133859),...

Plasmapheresis first or IVIG first in GBS? What other treatment options are there for severe disabling GBS?

In FRAIL-AF, switching VKA therapy to a NOAC was associated with higher risk of bleeding in elderly, frail patients. 

Given the risk of elevated ICP, would you attempt a brain MRI to further characterize the lesion? Or would CT imaging suffice prior to intervention?

In FRAIL-AF, participants were switched from VKA to dabigatran, rivaroxaban, apixaban, and edoxaban.

For patients who are unable to have complete brain stem testing, would you recommend apnea testing prior to ancillary tests in case of suspected brain...

For instance, if the patient doesn’t tolerate apnea testing, is too unstable to go for ancillary testing outside the ICU, and TCDs/EEG are unava...

What is the cost and accessibility of CYP2C19 gene testing? Does the limited availability of rapid genotyping techniques limit the clinical applicabil...

How do you plan to incorporate the results of the CHANCE-2 trial (Wang et al., PMID 34708996) in your own practice?

Is there any benefit to starting hyperosmolar therapy prior to the development of depressed level of consciousness or midline shift?


Papers discussed in this category


Neurotherapeutics,

Lancet Neurol, 2017 Sep

The Lancet. Neurology, 2016-05

JAMA,

Contemp Neurol Ser,

N Engl J Med, 2021 Oct 28

The New England journal of medicine, 2018-07-19

N Engl J Med, 2013 Jun 26

N Engl J Med,

The New England journal of medicine, 2002-02-21

N Engl J Med, 2013 Nov 17

Cureus, 2022 Sep 11

Crit Care, 2020 Jan 06

The Lancet. Neurology, 2007 Mar

Stroke, 2022 May 17

Circulation, 2023 Aug 27

Neurology, 2020 Sep 01

Lancet Neurol, 2021 Mar 17

Neurocritical care, 2005

Clinical neurophysiology practice, 2022 May 16