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Do you utilize a V80Gy dose constraint for the rectum for definitive dose-escalated RT of the prostate?

Standard RTOG constraints include guidelines for rectal v60, v65, v70, v75, but is there a relative or absolute volume constraint for rectal v80 that predicts for toxicity?
2 Answers
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Radiation Oncology · Virginia Commonwealth University Medical Center
Answered on

I generally treat to 78 Gy in 2 Gy fractions or to 79 Gy in 1.8-2 Gy fractions, so I'm very concerned about hot spots and where they are located. I try hard to keep the rectal Dmax less than 80 Gy. That's not always possible. I will accept max doses up to about 82.5 Gy if the volume is not more than 1-2%, and it doesn't extend to the mucosal surface. I have not seen guidelines addressing doses of 80 Gy and up for prostate EBRT, but we know from the old days looking at point doses to the rectal m...

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Mednet Member
Radiation Oncology · Northeast Alabama Regional Medical Center
Answered on

For many, many years I have treated the prostate (CTV) to a minimum dose of 81 Gy based on MSKCC data that was initially appearing in the late 90's (3DCRT data) and refined/updated later with IMRT data. I'll freely admit I've been a fan of the MSKCC approach/data for a long time. What I'm not so much a fan of is a "constraint" per se in any radiation planning, and I also freely admit a little heresy in that regard. Certainly you don't want to "blow past" known DVH metrics where toxicity is known...

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