Does a negative staging PSMA PET in a patient with biopsy-proven recurrent prostatic adenocarcinoma change your management?
I have a pair of patients with MRI+ and biopsy+ disease who have staging PSMA PET/CT that do not show disease within the prostate (or anywhere else). Do we think this tells us something about the biology of the disease?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of British Columbia
Answered on
The bottom line is that you have to believe the biopsy. PSMA PET will not show microscopic disease, which is why it cannot "rule out" disease in lymph nodes or elsewhere. It is comforting when it is negative, but it is not absolute truth.
A few questions; What was the PSA at the time of the PSMA PET...
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Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on · Updated on
The concordance between PET and MRI for recurrence is about 50%.
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