For a patient with breast cancer s/p lumpectomy found to have a heterozygous RAD50 mutation, is adjuvant radiation appropriate therapy or would you recommend completion mastectomy?

Topics: Breast Cancer • Radiation Oncology • Medical Oncology • Surgical Oncology • Breast Cancer, Non-metastatic

Answer from: Medical Oncologist at Academic Institution

Rad50 is part of the homologous recombination repair pathway. If cancer cells have homozygous loss of Rad50, they will be exquisitely sensitive to radiation therapy, which causes lethal DNA double-strand breaks via oxygen free radicals. Theoretically, adjuvant radiation is an excellent treatment bas...

Comments

Medical Oncologist at Southwest Medcl Consult SC
Since the risk of malignancy is increased in a pat...

Medical Oncologist at BronxCare Mount Sinai Comprehensive Cancer Care
Thank you. It was very helpful.

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