How do you approach EGFR mutated NSCLC with isolated progression in the chest who is planned for a course of radiation at least 3-4 weeks?

Topics: Radiation Oncology • Thoracic Malignancies • Medical Oncology • Non-small cell lung cancer • EGFR+

How do you balance the risk of an EGFR flare while holding osimertinib vs the risk of pneumonitis when continuing?

Answer from: Medical Oncologist at Academic Institution

This is an interesting question without a clear answer. There are two competing risks associated with either decision. The risk of continuing osimertinib while radiating chest disease is clearly that of pneumonitis with the overlapping risks from radiation and osimeritinib. The risk of holding osime...

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Radiation Oncologist at USC Keck School of Medicine
Thank you Dr. @Gregory A. Otterson for this c...

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