EGFR+   

Questions discussed in this category



How do you balance the risk of an EGFR flare while holding osimertinib vs the risk of pneumonitis when continuing?

Are there specific mutations or co-mutations were you would consider use of this agent? 

1st-line pembrolizumab is supposed to be used AFTER failure of appropriate targeted agents in this setting, but would you consider the reverse sequenc...

The EGFR subgroup appeared not have benefited as much as other patients in the publication. However, recently it was reported that the PACIFIC study m...

Does EGFR+ status influence your decision? What is the significance of this finding and its potential for progression? Is it simply occult disease con...


Papers discussed in this category


The New England journal of medicine, 2015-10-22

The New England journal of medicine, 2016-11-10

J Thorac Oncol,

Clin. Cancer Res., 2015 May 27

Lancet (London, England), 2017-01-21

Lancet (London, England), 2016-04-09

The New England journal of medicine, 2018-06-14

The Lancet. Respiratory medicine, 2019-05

Ann. Oncol.,

The New England journal of medicine, 2018-12-13

J. Clin. Oncol., 2019 Dec 11

Lancet Oncol., 2017 Sep 25

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-12-01

N Engl J Med, 2020 Sep 19

J Clin Oncol, 2020 Dec 04

Clin Oncol (R Coll Radiol), 2017 Nov 16

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014-06

Radiother Oncol, 2020 Jul 31

The Lancet. Oncology, 2015-07

Annals of oncology : official journal of the European Society for Medical Oncology, 2019-08-01

J BUON,

Br J Cancer, 2019 Sep 30

Biochemistry, 2015 Jul 06

N Engl J Med, 2019 Nov 21

Lancet Oncol, 2016 Apr 12

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2013-01

Future Oncol, 2018 Nov 08

World J Clin Cases,

Br J Cancer, 2016 Nov 22

Clinical cancer research : an official journal of the American Association for Cancer Research, 2011-10-01

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-01

Lung Cancer, 2020 Nov 13

Neuropathology, 2019 Mar 13

Respir Investig, 2014 Nov 13