Questions discussed in this category
With low #s of patients on the durvalumab PACIFIC trial with EGFR mutated disease, and LAURA trial design of osimertinib until progression, should we ...
Do you consider dose escalating to 160 mg or do you add chemotherapy to osimertinib?
Does the site of treatment factor into your decision?
Do you consider any neoadjuvant therapy or proceed to surgery followed by adjuvant chemotherapy and osimertinib? Does the type of mutation (ex a rare ...
Would you offer adjuvant atezolizumab, osimertinib, or neither? Both IMpower010 and ADAURA only had patients with EGFR exon 19 deletion or L858R mutat...
Would you consider the immune suppressed status of the patient as a high risk factor to offer adjuvant therapy?
How do you balance the risk of an EGFR flare while holding osimertinib vs the risk of pneumonitis when continuing?
Would you consider SBRT and continue osimertinib?
Are there specific mutations or co-mutations were you would consider use of this agent?
1st-line pembrolizumab is supposed to be used AFTER failure of appropriate targeted agents in this setting, but would you consider the reverse sequenc...
Would you continue osimertinib after radiation therapy, switch to crizotinib, or consider chemotherapy +/- immunotherapy?
Does EGFR+ status influence your decision? What is the significance of this finding and its potential for progression? Is it simply occult disease con...
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Papers discussed in this category
The New England journal of medicine, 2015-10-22
The New England journal of medicine, 2016-11-10
J Thorac Oncol,
Clin. Cancer Res., 2015 May 27
Lancet (London, England), 2017-01-21
Lancet (London, England), 2016-04-09
The New England journal of medicine, 2018-06-14
The Lancet. Respiratory medicine, 2019-05
Ann. Oncol.,
The New England journal of medicine, 2018-12-13
J. Clin. Oncol., 2019 Dec 11
Lancet Oncol., 2017 Sep 25
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-12-01
N Engl J Med, 2020 Sep 19
J Clin Oncol, 2020 Dec 04
Clin Oncol (R Coll Radiol), 2017 Nov 16
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014-06
Radiother Oncol, 2020 Jul 31
The Lancet. Oncology, 2015-07
Annals of oncology : official journal of the European Society for Medical Oncology, 2019-08-01
J BUON,
Br J Cancer, 2019 Sep 30
Biochemistry, 2015 Jul 06
N Engl J Med, 2019 Nov 21
Lancet Oncol, 2016 Apr 12
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2013-01
Future Oncol, 2018 Nov 08
World J Clin Cases,
Br J Cancer, 2016 Nov 22
Clinical cancer research : an official journal of the American Association for Cancer Research, 2011-10-01
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015-01
Lung Cancer, 2020 Nov 13
Neuropathology, 2019 Mar 13
Respir Investig, 2014 Nov 13
JACC CardioOncol, 2019 Dec 17
J. Clin. Oncol., 2008-07-20
J Clin Oncol, 2021 Nov 02
Lancet, 2021 Sep 20
FEBS J, 2009 Nov 18
Clin Lung Cancer, 2018 May 01
J Thorac Oncol, 2021 Feb 01
ESMO Open, 2021 Sep 17
J Clin Oncol, 2019 Dec 06
Ann Oncol, 2020 Jul 05
J Thorac Oncol, 2021 Aug 19
Clin Transl Sci, 2023 Feb 19
N. Engl. J. Med.,
J Clin Oncol, 2011 Nov 28
J Clin Oncol, 2019 Jun 13
J Clin Oncol, 2022 Aug 12
J Thorac Oncol, 2023 Feb 23
Future Oncol, 2021 Jul 19
J Clin Oncol, 2023 Jan 31
The Lancet. Oncology, 2014-01
JTO clinical and research reports, 2022 Apr 21
The New England journal of medicine, 2023 Nov 08
The New England journal of medicine, 2024 Jun 02
The New England journal of medicine, 2018-01-11
J Clin Oncol, 2021 Aug 2
The New England journal of medicine, 2023 Oct 21