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How do you manage a patient with metastatic NSCLC whose initial mutation testing was limited or results are no longer available?

How do you operationalize finding biomarker information in EHRs/testing portals, either for your own patients or if they have changed providers? If a patient has been on extended duration of 1L treatment and initially had only limited biomarker testing, do you retest full NGS?
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For a patient with NSCLC whose initial genomic sequencing is incomplete/unavailable, would you repeat testing prior to 2nd line treatment?

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4 Answers
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Medical Oncology · Johns Hopkins University/Sidney Kimmel Cancer Center
Answered on

If I see a patient with new metastatic NSCLC with limited/no next-generation sequencing (NGS) testing, I will attempt to initiate testing in some way while formulating a treatment plan. Specifically, I will either attempt to do tumor based NGS if feasible and timely (goal for getting results back in...

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Medical Oncology · Moffitt Cancer Center
Answered on

I agree this is a great question and I agree with what had already been said- the only point I would add is the importance of recognizing what it means for mutation testing to be 'insufficient'.

I believe this is not only in cases where a few genes were tested, but also in cases where liquid biopsy...

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Medical Oncology · Roswell Park Comprehensive Cancer Center
Answered on

Many commercial test vendors generally host their own online "portal" for results with a search function thus it is helpful to create an account, some of which can also be enabled to permit administrative personnel to centrally manage all incoming results for a group practice. Thus, if the ordering ...

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Medical Oncology · UCI Health
Answered on

This is a great question and comes up often. I tend to do liquid biopsy right then and there and order the tissue re-biopsy if there is a lesion that would be amenable for a biopsy. If we are lucky and there are positive liquid biopsy results, I might cancel the tissue biopsy but I do think that eve...

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