Targeted therapies   

Questions discussed in this category

How do you operationalize finding biomarker information in EHRs/testing portals, either for your own patients or if they have changed providers? If a...

Is there evidence or experience to support use of targeted therapy for KRAS G12C mutated NSCLC as first line in place of chemotherapy? 

How do you weigh the various efficacy endpoints in the trials of novel combinations in ccRCC?  Are there specific clinical populations that you ...

Although a small subset, do you generally move these patients directly on to chemotherapy +/- immunotherapy or does it depend on the specific mutation...

Literature regarding treatment of diarrhea due to Trametinib is limited and does not address safety of Lomotil.

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-12-01

N Engl J Med, 2020 Sep 19

J Clin Oncol, 2020 Dec 04

The New England journal of medicine, 2012-07-12

The New England journal of medicine, 2018-05-31

The New England journal of medicine, 2018-06-14

Annals of oncology : official journal of the European Society for Medical Oncology, 2019-08-01

Clin Lung Cancer, 2021 Jan 27

Eur J Cancer, 2021 Apr 01

Lancet Oncol, 2019 Oct 25

Cancer, 2022 Apr 05

Lancet Oncol, 2021 Jan 18

The New England journal of medicine, 2016-11-10

J Clin Oncol, 2019 Dec 06

Ann Oncol, 2020 Jul 05

J Thorac Oncol, 2021 Aug 19

Clin Transl Sci, 2023 Feb 19