How would you approach local therapy (surgery or RT) in a patient with radiographic complete response after chemoimmunotherapy for non-small-cell lung cancer?

Only 1/96 patients (0.6%) of patients on CheckMate 816 had a complete response by RECIST so I don't think our current paradigms are really driving these kinds of responses. Additionally, there is clearly a disconnect between clinical response rates by RECIST (0.6%) and pathologic complete response (...

So many good answers here already. I do get asked this frequently by my residents, so giving a short educational answer about "how I do it" might add a bit to these replies.

Firstly, the patient should get surgery if they are a candidate and willing to undergo resection. The data for induction with...

It’s hard to envision a scenario with CR. No residual scar tissue. Full dose RT or resection.