In light of the STAMPEDE data on the addition of docetaxel or abiraterone, what is now your initial treatment for young, healthy men with high-grade prostate cancer (Gleason 9-10) with relatively asymptomatic metastatic castration-sensitive disease?
Answer from: Medical Oncologist at Academic Institution
Data from both the Latitude and Arm G of the Stampede study provides patients/physicians with additional choices/challenges given prior data from early presentations of Stampede and CHAARTED. There is of course no data to address the optimal approach to the young man with high grade disease. &...
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Answer from: Medical Oncologist at Academic Institution
The LATTITUDE trial was specifically designed for this very question, and enrolled fit men with high grade Gleason 8-10 cancers and M1 disease. They differed slightly from the high volume CHAARTED patients, but largely overlap given that 2 of 3 "high risk" features were required (Gleason 8-10,...