What are best practices for radiation oncology patient and staff precautions with the COVID-19 pandemic?   

I know many centers are exercising extra precautions in light of the new concerns with coronavirus. How are people explaining things to their patients and staff?

Question Created by Suketu Patel


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Elizabeth Nichols, University of Maryland
Added March 14, 2020
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Radiation Oncologist, Community Practice (Northeast)
January 31, 2021

We are still learning about COVID-19 immunity! We now know that people who have serum tested positive for antibodies at one time might lose their antibodies on subsequent testing. Are there any HR policies regarding the frequency of antibody testing in medical personnel?

Radiation Oncologist, Radiation Oncology, Community Practice (Northeast)
January 31, 2021

Great update, thanks. I am curious how many facilities continue to treat when a patient becomes COVID positive, like you do. I am impressed that there have been no cases of staff to patient transmission or patient to staff transmission, which shows the effectiveness of your current policy of surgical masks and eye protection combined. I assume that you educate your staff and patients on the proper way to wear masks, as masks that don't cover the nose are almost worthless.

A few points need emphasizing:

1. In most settings: surgical masks work just as well as N95 masks in preventing respiratory infections. N95 masks reliably block 0.3 micron particles, and surgical masks reliably block 3 micron particles. Thus you would think that N95 masks should be far better given the fact that individual corona viruses are 0.05 to 0.2 microns in size. However, volume is dependent on the radius cubed, so a 10 fold smaller droplet/particle will carry 1,000 fold less virus. Most respiratory virus transmission involves droplet sizes reliably blocked by surgical masks as shown by a number of randomized trials comparing N95 vs surgical masks such as:

A randomized trial involving 2862 healthcare workers comparing N95 vs surgical masks showing similar protective effects: Radonovich Jr. et al., PMID 31479137.

A randomized trial involving 446 nurses comparing N95 vs surgical masks showing similar protective effects: Loeb et al., PMID 19797474.

2. Mask wearing can never provide 100% virus protection for the wearer. But the low dose of virus that is inhaled is unlikely to cause serious infection. It is apparent that disease severity depends on the initial inoculum size, with the higher the inoculum size the worse the subsequent disease. Thus mask wearing may be a form of vaccination by resulting in a subclinical infection, and some degree of immunity. (This is similar to the old practice of protecting against smallpox by pricking a patient with a needle that had been used to prick a pox lesion, aka "Variolation".) This was well discussed in a recent NEJM paper. Gandhi and Rutherford. PMID 32897661.

3. Even if we have had the vaccine, we still need to wear masks. The current vaccines are based on the genetic sequence of the original Wuhan virus. As new mutations appear, the current vaccines will provide progressively less protection. Thus for the sake of our patients and ourselves, we still need to wear masks as long as this epidemic continues.

I hope everyone stays healthy.


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Hiram Gay, Washington University School of Medicine
Added March 14, 2020
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Radiation Oncologist, Radiation Oncologist , Community Practice (Northeast)
March 15, 2020

Article about ACE2 inhibitors

https://www.medscape.com/viewarticle/926665.

Radiation Oncologist, Associate Professor, Academic Institution (South)
March 17, 2020

First off, @Hiram A. Gay. You have written one of the best explanations about how we as radiation oncologists can conceptually think about COVID-19 in the clinic.

Onto your last thought, I also think we may wish to be thinking about clinical trials for patients who test positive for COVID-19 that also need treatment, which is what I think you were alluding to with the ACE2 receptor question. There are many ways conceptually that this can be addressed and I will leave these approaches to those in academic institutions. However, there is data that is coming out with potentially available drugs, chloroquine (and hydroxychloroquine), that have been tested already with radiation and/or chemotherapy. Xu R, et al. "The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers: A systematic review and meta-analysis." Medicine (Baltimore) 2018 Nov. 

Chloroquine has been identified as having a promising profile against the new SARS-Cov-2 coronavirus that causes COVID-19 by the China National Center for Biotechnology Development and is currently being tested as an ant-COVID-19 therapy. No trials involve oncology patients to the best of my knowledge.

Chloroquine is one of five drugs approved for the tentative treatment of COVID-19 in version 6 of the National Health Commission of the People's Republic of China Guidelines for the Prevention, Diagnosis, and Treatment of Novel Coronavirus-induced Pneumonia. ref Dong L et al. "Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics. 2020. 

Chloroquine's relevance to ACE2 is that the anti-SARS-Cov-1 effects of chloroquine in-vitro were attributed to a deficit in the glycosylation of a ACE2 receptor. The reference is: Christian A. Devaux, Jean-Marc Rolain, Philippe Colson, Didier Raoult, New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?, International Journal of Antimicrobial Agents (2020).

There are other drugs that may also be worthwhile Dong L et al. "Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discoveries & Therapeutics. 2020; 14(1): 58-60. I do not believe the other drugs relate to ACE2, but quite frankly, I do not know.

I am not a pharmacologist and I am in no way an expert in COVID-19, but with this pandemic, I think it will impact cancer care and our patients. In my opinion, the academic institutions and our government need to be leaders as this evolves and provide guidance as we start having to treat patients who test positive with minimal symptoms.

I appreciate Hiram that you have taken this leadership role for our community.

Radiation Oncologist, Professor, Academic Institution (Midwest)
March 23, 2020

Thanks @David E. Morris, I appreciate your kind comments. Hiram


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Edward Kim, University of Washington
Added March 14, 2020
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Eli Finkelstein, Locum Tenens
Added March 16, 2020
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Radiation Oncologist, Community Practice (Midwest)
March 25, 2020

This post is better written and more helpful than any "official" guidelines I have seen. 

Radiation Oncologist, Radiation Oncology, Community Practice (Northeast)
March 26, 2020

@Jeffrey Kittel, MD Thanks, I appreciate your kind comments. 


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Brian Baumann, Washington University School of Medicine
Added March 16, 2020
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Radiation Oncologist, Associate Professor, Academic Institution (South)
March 17, 2020

That flowchart looks worse than the details of the Krebs Cycle that I still have nightmares from as a 1st-year medical student.

Radiation Oncologist, Community Practice (South)
April 12, 2020

The CDC risk stratification and this flowchart seem to indicate that they apply to confirmed COVID-19 positive patients. Because most of our patients are in the clinic daily prior to potentially testing positive, when (prior to a positive test) would you consider a patient a potential staff exposure risk? When symptoms developed? An arbitrary number of days prior to the test or symptoms?


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Elizabeth Nichols, University of Maryland
Added March 19, 2020
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Elizabeth Nichols, University of Maryland
Added March 16, 2020
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Stacy Wentworth, Atrium Health Wake Forest Baptist
Added March 24, 2020
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Elizabeth Nichols, University of Maryland
Added March 26, 2020
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Elizabeth Nichols, University of Maryland
Added March 26, 2020
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Matthew Mumber, Harbin Clinic
Added March 25, 2020
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Nagla Abdel Karim, Inova-University of Virginia
Added April 21, 2020
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