Should radiation therapy be offered to the prostate +/- pelvic nodes in a patient who had PSMA PET/CT positive pelvic LN and prostate disease that resolved after a year of ADT?

Difficult to say but.......PSMA (Prostate specific membrane antigens) PET scans, are undergoing active clinical trials is seemingly the way of the future for imaging in most PCs cases as opposed to the current use for Axumin PET scans which are used for PSA progression only, to date.

In this patient's case, because he only received only ADT, a "cure" in the real sense of the word in cancer care is unlikely.

As such, even if the disease "disappeared" per repeated PET, I would push for biopsies at both previous sites - to confirm CR status. Without biopsy confirmation, my instinct is to irradiate the patient PC and LNs after re-staging or place him in a clinical trial. Presumably, he will remain in the oligo-met category which makes him pote...