What approaches can we take to initiate therapy and improve survival rates in patients with HLH?

At our institution, we have comprised a multidisciplinary team to help treat these patients. The team or "HLH task force" as we like to call ourselves is comprised of a clinical immunologist, rheumatologist, dermatologist, critical care physician, hepatologist, BMT attending/hematologist, infectious disease physician, and pathologist. The task force came to be after we all were on cases together where we realized that if the diagnosis was made sooner, we could have initiated therapy earlier and ...

Agree on a multi-specialty approach for early input regarding the assessment and management of sHLH/MAS. While the multi-system inflammatory phenotype of COVID-19 is unique, one outcome of the pandemic was accelerating this type of approach to patients admitted with multi-system organ dysfunction. Early diagnosis is paramount to optimizing outcomes - probably the single most effective measure to currently effect this is to establish a culture whereby serum ferritin is ordered and tracked (MAS no...