What is the benefit of cytoreduction with Hydroxyurea for patients with newly diagnosed chronic phase CML with a WBC count >100 prior to the initiation of a TKI?

Topics: Hematologic Malignancies • Pediatric Oncology • Medical Oncology • Leukemia • Myeloproliferative Neoplasms • AYA • Hematology

Answer from: Medical Oncologist at Academic Institution

For newly diagnosed patients with CML, there is no benefit to using hydroxyurea before TKI. Using HU oftentimes ends up causing cytopenias and it then makes it challenging to keep patients on their TKI when it is started. There are some scenarios where it is reasonable to use- if you don’t yet...

Comments

Medical Oncologist at Kaiser Permanente-Santa Teresa-San Jose
Hydroxyurea effects are short lived and, when used...

Medical Oncologist at Massachusetts General Hospital
Agree! The key term is used properly. The cytopeni...

at Emory University
What about in a patient with extreme leukocytosis ...

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