When do you initiate androgen deprivation therapy for biochemical relapse of prostate cancer following primary therapy?
Do you use a PSA threshold, PSA doubling time, or only evidence of metastatic disease to trigger ADT? For those without rapid doubling time, do you ever start ADT without metastatic disease?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · University of Minnesota–Masonic Cancer Center
Answered on
There is no right or wrong answer here. The Johns Hopkins approach is to always recommend a clinical trial for the nonmetastatic BCR population. In the absence of a trial, our group does not believe that early ADT is justified in men with PSADT >9 months, where metastasis-free survival approaches 10...
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