When do you recommend induction chemotherapy prior to concurrent chemoradiotherapy for locally advanced NSCLC?

I rarely recommend induction chemotherapy prior to definitive concurrent chemoradiation. This is because two randomized studies, LAMP (PMID 16087941) and CALGB 39801 (PMID 17404369) showed no survival benefit and added toxicity with induction chemotherapy compared to concurrent chemoradiotherapy alo...

Agree. My first response was to say "never" but I would revise to "almost never".

If you have a patient with a large tumor volume where your normal tissue dose is high and you feel likes its a high risk plan, I would not anticipate that you can make it significantly better after what is usually a fa...