When treating stage IVB cervical cancer with both systemic chemotherapy and local pelvic radiation therapy, do you incorporate the use of bevacizumab as in GOG 240?
Consider treatment of stage IVB cervical cancer with systemic therapy and local pelvic radiation therapy as in Perkins et al., PMID 31810653.
Answer from: Radiation Oncologist at Academic Institution
I generally favor starting with multi-agent systemic therapy (Carbo/Taxol/Avastin +/- Pembro) upfront to confirm that the patient is going to respond appropriately and not blossom with metastatic disease prior to making a decision of radiating the pelvis in oligometastatic cervical cancer, similar t...
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Answer from: Radiation Oncologist at Community Practice
Would hold bev for 4 weeks prior to and after EBRT due to the risk of small bowel bleeding.Crane et al., PMID 16505434Xiu et al., PMID 35770233