Would you consider observation instead of a Whipple in a borderline resectable pancreatic cancer patient treated with neoadj CRT who has a radiographic CR?

There are always many reasons for not doing a Whipple. While it is the one intervention that increases survival most significantly for this disease, it is still rarely curative in the long term and comes with surgical morbidity. Therefore patients with potentially unresectable disease, or with a bad PS, or medical comorbidities, are often passed up for the procedure. But absent any of those (or other) contraindications, I would not let a radiographic complete response hold up the procedure. The ...