Would you have a patient temporarily discontinue methotrexate while receiving a FAST or FAST FORWARD regimen for breast irradiation?

The patient is on a dose of 22 mg of methotrexate weekly for severe rheumatoid arthritis.

If you would discontinue the methotrexate, how long would you suggest the patient remain off of the medication before resuming?

Answer from: Radiation Oncologist at Community Practice

I favor continuing as the dose of MTX is low for RA and in CMF era with much higher methotrexate dose, RT plus MTX was well tolerated.

Comments

Radiation Oncologist at Emory University
Yes, previous combination of CMF with RT suggests ...