Can you safely proceed with breast irradiation during treatment with immunotherapy?
For a node positive, triple negative patient that underwent neoadjuvant chemotherapy followed by breast conservation with a complete pathologic response now receiving immunotherapy, would concurrent radiation be safe to administer to the breast?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
In KEYNOTE-522, RT was done with concurrent Pembro after NACT plus IO and no significant additional untoward effect was reported. So, we do RT routinely with Pembro for these patients.
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Radiation Oncology · Cedars-Sinai Medical Center
Answered on
I agree with Dr. @Dr. First Last's response. In my clinical practice, I also routinely proceed with adjuvant RT during the adjuvant immunotherapy portion of these patients' treatment. I do discuss the exceedingly low risk of radiation pneumonitis with these patients (not outside of my usual clinical...
Join for free or sign in to see the full answer