Pediatric Hematology/Oncology

Bone Marrow Failure

Questions discussed in this category

How would you manage aplastic anemia refractory to multiple agents?

Treated initially with hATG/CNI/TPO, but then relapsed. Subsequently treated with cyclosporine, danazol, ESA, and alemtuzumab, but still with pancytop...

1 Answer available

In pure red cell aplasia, does peripheral blood-positive IgG for parvovirus have significance if persistently positive on retesting, but IgM and PCR are negative?

The patient has a recurrence of the disease despite tapering prednisone and cyclosporine. Bone marrow exams x2 without MDS. Testing for all other caus...

1 Answer available

How do you decide between HSCT and immunosuppressive therapy for treating hepatitis associated aplastic anemia?

1 Answer available

How would you work up a mildly neutropenic patient (ANC >800) with family history of neutropenia and personal history of occasional mouth sore?

What are indications to order gene mutation studies (e.g. ELANE) and how would it help the patient?

1 Answer available

When would you consider transplant for a patient with a bone marrow failure syndrome (FA, DC, etc.)?

2 Answers available

How would you manage a patient with severe aplastic anemia and a large PNH clone?

1 Answer available

Would you stop current immunosuppressive therapy or delay starting immunosuppressive therapy in a patient with aplastic anemia who has been infected with COVID-19?

2 Answers available