General Primary Care   

How do you counsel patients on this off-label use?

Are there any pearls for strong factors that would push you towards vs away from deprescribing?

(i.e., isolated elevation in MCHC, RDW.) Especially when all other lab results are normal and reassuring.

For your recommended medication, are you doing a scheduled set dose, or is it primarily symptom-driven? 

I.e., adrenal/renal mass vs cysts, pancreatic lesions 

What medical co-morbid conditions are most helpful when trying to decide which agent to start with?

Was the change that was noted in the trial clinically meaningful?Study reference: Baker et al., PMID 40720610

Considering the recent article in CHEST that describes the increasing incidence of fungal pneumonia Azar. Chest 2024

Risk factors such as hereditary thrombophilia without personal thrombosis, family history of thrombophilia or thrombosis, etc.

Do you routinely rule out secondary causes of osteoporosis (i.e., TSH) in all patients prior to starting therapy? If you work up all patients, what la...

In light of publication from Ihara et al in Cephalagia 2025 Dec

Are there situations in which you still feel comfortable giving IV iron? If not, do you consider PO iron?

Lee et al., PMID 40366680

Specifically, what guidelines do you use to help determine this (if any)? 

Do you prescribe it universally or based on specific risk factors?

Are there any good reviews or recent literature you recommend about this to non-addiction medicine providers? 

As studied here: Fitzpatrick MB, Behrens CM, Hibler K, et al. Clinical Validation of a Vaginal Cervical Cancer Screening Self-Collection Met...

Do you still find urinalysis helpful in this situation, or do you rely on more specific culture data, imaging studies, etc.?

If so, you have a recommended tapering strategy? 

As studied in Tang H, Donahoo WT, DeKosky ST, et al. GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related De...

How do you risk-stratify this otherwise low-risk young patient given the lack of specific guidelines for this rare cancer? Additionally, at what point...

How do you approach shared decision-making when patients express hesitancy about medication exposure in utero? What is your approach when a patient is...

In other words, are there benefits to identifying URI pathogens that do not necessarily have targeted therapies (e.g., rhinovirus, non-COVID-19 Corona...

Are there certain modifications to the home or aid devices that you commonly recommend? Some that are more cost-effective? 

Related Mednet discussion on low libido and SSRIs

What strategies do you use to counsel patients on continuing an antidepressant until therapeutic doses versus switching agents if they perceive a lack...

Is there a role, or do you find it largely drives the fixation of health being based on the number on the scale? 

Does your approach change with venous vs arterial contrast?

Prompted by nonspecific symptoms that could be related to low testosterone or many other conditions (i.e., fatigue, poor sleep) especially with all th...

Are there situations in which you would continue the possible offending agent with close monitoring?

Any specific lubricant more effective than another? 

What are your next diagnostic steps/tests?

For example, do you find trending WBC, procalcitonin, CRP, etc., more or less helpful?

Do you extend the course of fidaxomicin past initial 10 days to at least 3-7 days after completion of antibiotics?

For example, if someone has an upcoming vacation or family gathering, is it okay to temporarily stop their medication to increase their appetite?

For example, do you routinely supplement with calcium carbonate, magnesium hydroxide, aluminum hydroxide, simethicone, sucralfate, etc.?

For example, do you find it most useful for outpatient disease assessment/management, consideration of further imaging or specialist referral, or tria...

Do you use the traditional strict limit of 1.5 L, or do you consider removing more volume if a patient appears to tolerate it?

What non-pharmacological interventions do you recommend? Do you routinely prescribe prophylactic laxatives to patients initiating opioids? How do you ...