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Radiation Oncology

Gastric Cancer   

Questions discussed in this category

How do you treat locally advanced, operable, Siewert 3 GE junction adenocarcinomas?
3 Answers available
What are your top takeaways from ASCO GI 2023?
What were your “top 3” presentations/studies coming out of the meeting this year and how will it impact your own clinical practice? ...
8 Answers available
Do you recommend definitive chemoradiation for unresectable gastric adenocarcinoma in a medically unfit patient?
If so, what dose-fractionation regimen do you utilize? What are your target volumes?
2 Answers available
What is the role of adjuvant radiation for gastric cancer found to be locally advanced after up-front surgery in the setting of
NCCN recommends floropyrimidine-based chemoradiation (sandwiched by 5-FU or capecitabine), but many medical oncologists are utilizing multi-agent chem...
2 Answers available
What would your approach be for a patient with early stage gastric cancer who declines a gastrectomy?
2 Answers available
How do you select neoadjuvant chemo vs chemoRT in locally advanced, resectable GEJ/esophageal tumors?
NCCN recommends perioperative FLOT or FOLFOX vs. neoadjuvant chemoRT with Carboplatin/Paclitaxel or FOLFOX.Does CM-577 and the approval of nivolumab p...
9 Answers available
Can the results of Checkmate 577 be applied to patients who do not undergo surgery following chemoradiation because of a clinical complete response?
What about for a patient with complete radiographic response who declines surgical management?
3 Answers available
Can CM577 regimen of adjuvant nivolumab s/p neoadjuvant chemoRT with residual disease following surgery be extrapolated to patients with R1 resection unable to undergo re-resection?
CheckMate 577 only included patients with R0 resection.For R1 resections, guidelines suggest observation vs re-resection only.  
3 Answers available
Would you consider perioperative chemotherapy in an anastomotic recurrence of gastric cancer after partial gastrectomy who did not receive prior chemotherapy or radiation?
2 Answers available
How do you manage a patient with gastric/GE junction carcinoma who has positive lymph nodes at resection after neoadjuvant chemotherapy?
If you would elect for adjuvant therapy, which study helps guide your choice of regimen?
1 Answer available
How would you treat an early-stage gastric adenocarcinoma in a patient who is medically inoperable and not fit enough for chemotherapy?
Is there such thing a definitive radiotherapy in this setting, or would this be a purely palliative approach? If you would treat, what would your targ...
3 Answers available
What adjuvant therapy do you give after surgery to patients with gastric CA who undergo 3 cycles of FLOT with no tumor effect on pathology and maintain good PS?
I understand the perioperative trials are not based on tumor regression in cancer cells.
3 Answers available
Would you recommend adjuvant chemoradiation for T1N0 gastric adenocarcinoma status post R0 resection but no D2 lymph node dissection?
Does the lack of D2 dissection automatically necessitate adjuvant chemoradiation therapy (ie <5 LN obtained)? Would the presence of high risk facto...
1 Answer available
What are your treatment volumes for patients with gastric cancer receiving adjuvant chemoRT for a positive margin following gastrectomy and D2 nodal dissection?
Will you treat only the anastamosis and remnant stomach without elective nodal RT, or will you include elective nodal RT in your treatment fields, ass...
1 Answer available
Which regimen is better for gastric adenocarcinoma- neoadjuvant chemotherapy or adjuvant chemoradiation?
Is there a consensus on the MAGIC v. MacDonald debate?
2 Answers available
Should I use PET/CT for GE junction treatment planning?
We use PET for esophageal, but not gastric cancer. GE junction seems like a grey area. 
1 Answer available
Do you stage and treat GE junction tumors like gastric or esophageal cancer?
Does the advent of FLOT in gastric cancers, change your approach to GE adeno's? Would anyone consider FLOT followed by chemoradition followed by surge...
1 Answer available
Do you ever give postoperative chemoradiation in patients who underwent preoperative chemotherapy for gastric adencocarcinoma?
1 Answer available


Papers discussed in this category

N Engl J Med, 2006 Jul 6
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer.
The New England journal of medicine, 2001-09-06
Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction.
BMC Cancer, 2015-07-21
TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG).
J. Clin. Oncol., 2009-02-20
Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction.
Annals of surgical oncology, 2016-11
What's the Best Way to Treat GE Junction Tumors? Approach Like Gastric Cancer.
The Journal of thoracic and cardiovascular surgery, 2007 Aug
Lymph node involvement in advanced gastroesophageal junction adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-07-01
Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection.
J. Clin. Oncol., 2016-08-10
Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial.
Lancet Oncol., 2014-07-01
Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial.
Ann. Oncol., 2014-07-01
Randomized trial on adjuvant treatment with FOLFIRI followed by docetaxel and cisplatin versus 5-fluorouracil and folinic acid for radically resected gastric cancer.
J. Clin. Oncol., 2015-10-01
Phase III Trial to Compare Adjuvant Chemotherapy With Capecitabine and Cisplatin Versus Concurrent Chemoradiotherapy in Gastric Cancer: Final Report of the Adjuvant Chemoradiotherapy in Stomach Tumors Trial, Including Survival and Subset Analyses.
J Clin Oncol, 2012 Jan 20
Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial.
International journal of radiation oncology, biology, physics, 2005-12-01
An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach.
Lancet Oncol., 2015-09-01
Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial.
The New England journal of medicine, 2002-10-17
Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.
Ann. Surg., 2007-11-01
The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma.
N Engl J Med, 2021-04-01
Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer.
J Clin Oncol, 2021 Apr 23
Ten-Year Outcome of Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal Cancer: The Randomized Controlled CROSS Trial.
Lancet,
Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research.
BMC Cancer, 2016 Jul 19
ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286).
Lancet,
Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer.
Cancer,
A comparison of combination chemotherapy and combined modality therapy for locally advanced gastric carcinoma. Gastrointestinal Tumor Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005-02-20
Paclitaxel-based chemoradiotherapy in localized gastric carcinoma: degree of pathologic response and not clinical parameters dictated patient outcome.
Lancet Oncol., 2018 Apr 09
Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial.
Lancet, 2019 Apr 11
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial.
Ann. Surg. Oncol., 2017 Mar 23
TOPGEAR: A Randomized, Phase III Trial of Perioperative ECF Chemotherapy with or Without Preoperative Chemoradiation for Resectable Gastric Cancer: Interim Results from an International, Intergroup Trial of the AGITG, TROG, EORTC and CCTG.
Ann Oncol, 2020 Nov 20
Adjuvant chemotherapy is superior to chemoradiation after D2 surgery for gastric cancer in the per-protocol analysis of the randomized CRITICS trial.
Annals of surgery, 2009-05
Post-treatment endoscopic biopsy is a poor-predictor of pathologic response in patients undergoing chemoradiation therapy for esophageal cancer.
J Gastrointest Surg, 2011 Sep 22
Defining a high-risk subgroup of pathological T2N0 gastric cancer by prognostic risk stratification for adjuvant therapy.
The New England journal of medicine, 2013-10-31
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
N. Engl. J. Med.,
FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer.
Lancet, 2021 Jun 05
First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial.
Eur J Cancer, 2018 Aug 24
A randomised phase 2 trial of nab-paclitaxel plus gemcitabine with or without capecitabine and cisplatin in locally advanced or borderline resectable pancreatic adenocarcinoma.
NEJM Evidence, 2022 Jun 1
Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer

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