Radiation Oncology

NCI-CCC Breast Tumor Board Question

Questions discussed in this category

In which scenarios do you stage breast cancer using CT and nuclear bone scans versus PET-CT?

Would you offer definitive local therapy to a patient with ER/PR+, Her2 neg breast cancer with oligometastatic disease that responded well to CDK 4/6 inhibitor +AI, despite NRG-BR002 results?

Young healthy patient, ER/PR positive HER2 negative right breast cancer with a synchronous single site of oligometastatic disease in the right 4th rib...

2 Answers available

In which situations do you consider post-mastectomy radiation therapy when the patient has a localized node-positive breast cancer with a complete nodal response and minimal residual disease in the breast post-neoadjuvant chemotherapy?

1 Answer available

For a young patient who had a prior pCR to neoadjuvant therapy, would you consider systemic therapy after local resection and radiation of an isolated brain metastatic recurrence of triple negative breast cancer?

CNS recurrence occurred within two years of prior neoadjuvant therapy

1 Answer available

When do you add an adjuvant bone-modifying agent in patients with history of localized breast cancer?

Is there any role for denosumab? How do you counsel patients regarding the benefit of bisphosphonates on breast cancer outcomes?

3 Answers available

Would you recommend PMRT for a patient with a right breast mastectomy with closest margin less than 0.1cm?

3 Answers available

How should our selection for neoadjuvant chemotherapy for breast cancer change in light of COVID-19?

2 Answers available

Papers discussed in this category

The Lancet. Oncology, 2012-07

Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial.

Annu. Rev. Med., 2015 Aug 28

Adjuvant Bisphosphonates and Breast Cancer Survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-06-20

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A Cancer Care Ontario and American Society of Clinical Oncology Clinical Practice Guideline.

Lancet,

Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials.

Lancet Oncol, 2019 Feb 19

Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.

Lancet Oncol, 2019 Dec 02

Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial.

Lancet Oncol, 2017 Oct 13

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial.

JNCI Cancer Spectr, 2021 May 28

Amplification and Adjuvant Clodronate Outcomes in Early-Stage Breast Cancer in NSABP B-34 and Potential Impact on Clinical Practice.

Lancet Oncol., 2020 Feb 14

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China.

International journal of radiation oncology, biology, physics, 2005-07-15

Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiation.

J Clin Oncol, 2022 Jan 07

Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108).

Ann Surg,

Impact of Breast Surgery in Primary Metastasized Breast Cancer: Outcomes of the Prospective Randomized Phase III ABCSG-28 POSYTIVE Trial.

Breast Cancer Res Treat, 2009 Jun

Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy.

Annals of surgical oncology, 2018-10

Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01.

Lancet Oncol., 2015 Sep 09

Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial.

The Journal of community and supportive oncology, 2014-10

Informational needs and the quality of life of patients in their first year after metastatic breast cancer diagnosis.

Journal of the National Cancer Institute, 1996-10-16

Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers.

The oncologist, 2019-03

Long-Term Survival of De Novo Stage IV Human Epidermal Growth Receptor 2 (HER2) Positive Breast Cancers Treated with HER2-Targeted Therapy.

Breast cancer research and treatment, 2019-04

Examination of a paradox: recurrent metastatic breast cancer incidence decline without improved distant disease survival: 1990-2011.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2020 Apr 22

Defining oligometastatic disease from a radiation oncology perspective: An ESTRO-ASTRO consensus document.

Annals of oncology : official journal of the European Society for Medical Oncology, 2020 Sep 23

5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5).

Annals of surgical oncology, 2020 Oct 30

Benefits of Surgical Treatment of Stage IV Breast Cancer for Patients With Known Hormone Receptor and HER2 Status.

JAMA oncology, 2021 Jan 01

Safety and Survival Rates Associated With Ablative Stereotactic Radiotherapy for Patients With Oligometastatic Cancer: A Systematic Review and Meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology, 2021 Oct 19

ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 May 26

Impact of F-Labeled Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Versus Conventional Staging in Patients With Locally Advanced Breast Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN, 2020 Sep

Clinical Utility of 18F-FDG PET/CT in Staging Localized Breast Cancer Before Initiating Preoperative Systemic Therapy.

Radiology, 2012 Dec 06

Performance of FDG PET/CT in the clinical management of breast cancer.

Radiation Oncology

NCI-CCC Breast Tumor Board Question

Questions discussed in this category

Papers discussed in this category

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