Cancer Predisposition   

Questions discussed in this category



Should patients with moderate penetrance pathogenic variants be managed similar to BRCA patients and consider risk reducing contralateral mastectomy?&...

Genes such as ATM, CHEK2, PALB2, RAD51C/D, BRIP1 seem to show some potential increased risk of ovarian cancer. Should these patients under prophylacti...

What about a higher penetrance PV such as PALB2? See JCO OGR 8/2021 by @Mark E. Robson discussing management of non-BRCA pathogenic va...

In a scenario where patient's other clinical/familial risk does not sufficiently qualify them? See JCO OGR 8/2021 by @Mark E. Robson discussing manag...


Papers discussed in this category


J Clin Oncol, 2020 Oct 29

Semin Cell Dev Biol, 2011 Jul 28

Nat Med, 2019 Sep 30

Cancers (Basel), 2022 Apr 14

J. Clin. Oncol., 2021 Aug 10

Hered Cancer Clin Pract, 2021 Apr 01

Oncology research, 2018-04-10

Balkan journal of medical genetics : BJMG, 2023 May 02