Pruritus   

I have 2 male patients who have failed oral gabapentin (sedation), tacrolimus and opzelura both burned, doxycycline x 2 months. They complain of burni...

How do comorbid conditions weigh into this decision?

Do you view the difference threshold on itch NRS as clinically meaningful to patients?

For example, there was recently a study in JAMA showing efficacy in cholestatic pruritis.

What will be your strategy for monitoring for these?

ET is JAK2+