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Do you consider induction immunotherapy or chemoIO prior to chemoradiation for locally advanced PDL-1> 50% NSCLC if normal tissue constraints are not met?

Traditionally these patients may have received chemotherapy prior to chemoRT.
1 Answer
Mednet Member
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Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

If normal tissue constraints can't be met, or significantly higher chance of distant metastatic disease due to extensive local/regional disease, I would consider induction chemo/IO for patients with negative EGFR, ALK mutation and PD-1>1% before definitive chemo/RT in inoperable stage III NSCLC. Thi...

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