This is a great question, as the reality is that while there is data for the efficacy of neoadjuvant chemoimmunotherapy followed by surgery, the current data is insufficient to tell us whether this is actually the appropriate treatment.  Neoadjuvant chemoimmunotherapy studies (such as Chec...

Interesting question and something that is frequently discussed in tumor boards. Multistation N2 patients were not included in neoadjuvant trials and hence, any adaptation of this strategy to patients with advanced N staging would not be appropriate at this time. Further, given level 1 evidence from...