Do you hold immunotherapy when administering lung SBRT?

Good question, limited data to inform an answer.

An ongoing trial ("iSABR") in which we are participating involves giving durvalumab 5 days prior to lung SBRT for early stage NSCLC and then continuing that agent for a total of 5 cycles; data are maturing, so I can't offer an estimate of pneumonitis r...

@Dr. First Last wrote a very thorough answer and I agree with his conclusion that generally 'concurrent' ICI with thoracic SBRT is safe based on limited retrospective and prospective experiences. Our ongoing iSABR study has completed the Phase I safety portion. All 15 patients in the Phase I receive...

I do not routinely hold immunotherapy with lung SBRT. There is a substantial body of literature that suggests thoracic radiation is safe in tandem with immunotherapy, including several prospective trials (Welsh et al., PMID 32916308, etc). Furthermore, several ongoing trials are currently testing im...