For a young patient with small cell bladder cancer, what would you recommend following cisplatin + etoposide, if scans show no evidence of distant disease and repeat TURBT shows no malignancy?

Topics: Genitourinary Cancers • Bladder Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Vanderbilt • NCI-CCC GU Tumor Board Question

Answer from: Medical Oncologist at Academic Institution

We would proceed with locoregional definitive therapy with either radical cystectomy & PLND or (chemo)radiation. Would not rely on TURBT alone. Limited datasets from MDACC slightly favor radical cystectomy but there is no high level evidence comparing surgical vs (chemo)radiation consolidation s...

Answer from: Medical Oncologist at Community Practice

Agree with @Petros Grivas. A fraction of these patients can be cured, and therefore local definitive therapy should be encouraged. Multiple retrospective studies have compared cystectomy vs chemoradiation in patients with localized disease, and outcomes do not appear to differ significantly. In the ...

Comments

Medical Oncologist at US Onc Comp Cancer Centers of Nevada
I have stopped giving consolidation radiation ther...

Medical Oncologist at University of Michigan Medical School
I have started doing surveillance cystoscopies als...

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