Topics:
Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Yale • NCI-CCC Breast Tumor Board Question • Breast Cancer, Metastatic
For patients with metastatic HER2-null (IHC 0+) breast cancer, do you offer trastuzumab deruxtecan based on the DAISY trial results?
In the DAISY trial, ORR of 30.6% in T-DXd treated patients (n = 38) with HER2-null breast cancer
Answer from: Medical Oncologist at Academic Institution
DAISY trial was a small trial and the outcome was hypothesis generating rather than practice changing. With that said, I offer trastuzumab deruxtecan to patients with metastatic breast cancer even if HER2 IHC on biopsy of metastatic disease was 0 but historically, their primary tumor tested at least...
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Answer from: Medical Oncologist at Community Practice
This question begs another update for the ASCO/CAP guidelines on the description of HER2 positivity/negativity and/or HER2 low expressors. The first ASCO/CAP guidelines on HER2 interpretation in breast cancer were released in 2007 and subsequently updated in 2013 and 2018. The most recent updated 20...