How do you manage leptomeningeal carcinomatosis from a metastatic solid tumor?

Several factors are usually considered prior to deciding how to manage patients with leptomeningeal carcinomatosis from a metastatic solid tumor. These factors are tumor type, performance status, neurological status, the bulk of CSF disease, the extra-cranial tumor burden as well as the chance of th...

This article has a lot of issues.

First of all, authors claimed that this was a phase II clinical trial. However, there was no sample size justification. I believe that this was at most a retrospective analysis of prospectively collected data. And they included only 11 breast cancer patients.

Second, ...