A patient with LGG, IDHm, <40 yo, who has had a subtotal resection would qualify for high risk on the basis of the sub-total resection per RTOG 9802 eligibility criteria. On that trial, he would have been randomized to RT vs RT+PCV chemo.This trial showed a significant improvement in the PFS but ...

The management for classic WHO grade 2 gliomas is increasingly becoming complex, especially with recent results from the INDIGO trial. In the context of this patient, there are two favorable risk factors, i.e. age <40, and IDH mutated, also but the fact that there are two unfavorable risk factors...

One should first determine the reason that the tumor was sub-totally resected. A common reason is that the tumor is close to an eloquent area of the brain. If that is the case, I would recommend treatment because a tumor recurrence could cause functional deficit by invading the adjacent eloquent are...