How would you manage an older, frail ECOG 2 patient with stage II muscle-invasive bladder cancer with other competing risk of death?
If the patient has had prior prostate radiation and is not a surgical candidate, would you treat with systemic therapy alone?
What is the natural history/prognosis of untreated MIBC?
Answer from: Medical Oncologist at Academic Institution
Conceivably, treatment options are extremely limited for older, frail patients with localized muscle-invasive bladder cancer, who are not candidates for cystectomy or radiation. TURBT is a common practice in this patient population (Trulson et al., PMID 23817891), but without any improvement in outc...
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