How would you manage metastatic small cell/neuroendocrine bladder cancer after response to 6 cycles of platinum/etoposide?

Topics: Genitourinary Cancers • Bladder Cancer • Medical Oncology • NCI-CCC Tumor Board Question • UCSF • NCI-CCC GU Tumor Board Question

If any clinical benefit (ie. CR, PR or SD) would you consider switch maintenance avelumab, surveillance until progression, or an alternate regimen?

Answer from: Medical Oncologist at Community Practice

I would consider maintenance avelumab in patients with metastatic small cell carcinoma of the bladder achieving stable or responding disease after platinum-etoposide. Notably, the JAVELIN Bladder-100 trial that led to the approval of maintenance avelumab included urothelial carcinoma and not predomi...

Comments

Medical Oncologist at University of Washington School of Medicine
Excellent and thoughtful response by @Guru P. Sonp...

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