How would you treat margin positive, node positive (pN+) prostate cancer with detectable post-op PSA but negative PSMA-PET after radical perineal prostatectomy?

Topics: Radiation Oncology • Genitourinary Cancers • Prostate Cancer • Medical Oncology

How does margin positive influence your decision?

Answer from: Radiation Oncologist at Academic Institution

Ideally, enroll the patient in a clinical trial like NRG GU-008. Off trial, would treat with salvage RT to the prostate bed and lymph nodes with long term (2 years) ADT. You can consider an MRI to see if there's a nodule in the prostate bed to boost, which may be more likely given a positive margin....

Comments

Radiation Oncologist at Toledo Clinic Inc.
When you say salvage RT, do you mean waiting until...

Radiation Oncologist at Stony Brook University School of Medicine
If the PSA is detectable and rising, I consider th...

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
We generally wait until PSA is at least 0.1 prior ...

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