In a patient with metastatic TNBC on chemoimmunotherapy for several years and a near complete response, would you consider an immunotherapy holiday?

Hard to answer this question without understanding the context of the clinical scenario.

In the scenario of chemoimmunotherapy, I would drop off the chemo and maintaining single-agent immunotherapy.

If the patient has transitioned to immunotherapy alone, you can only use a maximum of two years (atezolizumab or pembrolizumab). There is no evidence that a drug holiday will help.

Theoretically, we talk about the overactivation of the immune system leading to immune exhaustion, which may reduce ant...

Immunotherapy for 2 years. Many patients want to continue beyond 2 years. Patient involvement is important in decision-making.