Triple negative   

Questions discussed in this category


In patients who have completed all adjuvant therapy. Similar test to what is available for stage 2 and 3 colon cancer patients by Natera.

Presuming that imaging does not show distant metastatic disease, what would you offer? What about if the patient were PD-L1 negative?

Patient has already received neo/adjuvant treatment with AC, paclitaxel, capecitabine, docetaxel, and carboplatin.

Do you have any experience with intra-pericardial chemotherapy administration, and if so, in what cases?

Does tumor size impact your recommendation? High grade? Young patient age?

Would it affect your decision whether original primary tumor and treatment was hormone positive or negative?

Options: 1) ddAC-T- surgery- adjuvant capecitabine if residual disease 2) weekly taxol/carbo x 12 followed by dd AC x 4 3) Keynote 522- pembro/taxo...

Would you consider use of immunotherapy with checking PDL1? What chemotherapy agents would you consider along with mastectomy/radiation?

Is there any evidence for sacituzumab govitecan (IMMU-132) in this situation with progressive systemic disease after prior anthracycline and taxane?

Would you consider still immunotherapy even if aggressive disease vs single agent chemotherapy?

Does the SYSUCC-001 trial presented at ASCO 2020 change your practice?

Patient previously received neoadjuvant carboplatin, anthracycline and taxane regimen and is BRCA negative.

Does the results of the tnAcity trial influence your decision in choosing a 1st line option?

Received neoadjuvant ddAC/T followed by adjuvant capecitabine for residual disease and found to have metastatic pulmonary nodules within months of sur...

Following SRS to the brain lesions, is it safe to closely follow the patient for recurrence?  

Why do the NCCN guidelines suggest using neoadjuvant therapy only for patients with T2 or greater tumors?

The patient was previously treated with TAC x 6 (cumulative Adriamycin dose of 300 mg/m2) for a triple negative breast cancer. Would you consider inco...

Are you using post-neoadjuvant Xeloda based on preliminary data from the CREATE-X trial? Does BRCA mutation influence your decision?

In a patient with isolated leptomeningeal disease (no systemic disease), would you still recommend systemic therapy?

(For instance, TCX4 instead of AC->T for smaller tumors?)Does this affect your decision about treating with neoadjuvant versus adjuvant chemotherap...


Papers discussed in this category


ESMO Open, 2016-01-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003-03-15

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-03-10

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-08-10

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015-04

Am J Case Rep, 2017-02-28

N. Engl. J. Med.,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-01-01

Breast Cancer Res. Treat., 2014-09-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-06-10

Lancet Oncol., 2014-06-01

Cancer, 2004-10-15

JAMA Oncol, 2020 Aug 13

J Natl Cancer Inst, 2018 Jun 1

Oncology reviews, 2017-03-03

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-10-01

JAMA Oncol,

PLoS ONE, 2016 Oct 14

Sci Eng Ethics, 2017 Sep 15

Lancet, 2015 Mar 02

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-07-01

Lancet Oncol., 2015-03-01

Ann. Surg. Oncol., 2013 Nov 23

NPJ Breast Cancer, 2016 Nov 16

N Engl J Med, 2018 Oct 20

Annals of oncology : official journal of the European Society for Medical Oncology, 2018-08-01

Ann. Oncol., 2010 Jan 29

N. Engl. J. Med.,

The New England journal of medicine, 2016-07-07

The Lancet. Oncology, 2018-04

J Clin Oncol. , 2019 Sep 1

J. Clin. Oncol., 2019 Dec 05

The New England journal of medicine, 2018-08-23

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009-05-20

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10

Chest,

Interact Cardiovasc Thorac Surg, 2014 Aug 20

Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-12-01

N Engl J Med,

JAMA Oncol, 2016 Mar

J. Clin. Oncol., 2016 Jan 19

Lancet, 2020 Sep 20

NPJ breast cancer, 2017

JAMA Oncol,

J Clin Oncol, 2020 Jan 13

Cancer, 2017-10-01

Clinical breast cancer, 2008-06

Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-02-01

Breast Cancer Res, 2020 Nov 04

Breast Cancer Res Treat, 2011 Jul 27

Clin Breast Cancer, 2019 May 24

JAMA Oncol,