What chemotherapy regimen do you recommend with radiation therapy for cervical esophageal squamous cell carcinoma?

I would use weekly carboplatin/paclitaxel in this setting. Fluoropyrimidine + platinum is reasonable but will likely be more toxic, and I'm not aware of any data indicating that it's a more effective regimen.

I have typically offered concurrent FOLFOX rather than 5FU/Cisplatin for definitive therapy of proximal esophageal cancers- either adenocarcinoma or squamous cell carcinoma. The former regimen is more likely to cause neuropathy but in my experience has been more tolerable than 5FU/Cisplatin. While not statistically significant, there were 6 toxic deaths in the 5FU/Cisplatin group versus 1 toxic death in FOLFOX group in PRODIGE5/ACCORD17 (p=0.066). Given the better convenience, perceived improvement in tolerability, and similar outcomes, I feel this is an appropriate 1st-line regimen to consider for definitive chemoradiotherapy.

I would have not employed Carboplatin/Paclitaxel when treating with definitive intent for a proximal lesion. While ...