Questions discussed in this category
In a patient who is not a surgical candidate, do you offer concurrent carbo/taxol rather than 5FU/oxaliplatin?
What is the risk of perforation / fistulization?
If so, how many cycles would you give? Both the MAGIC and FLOT trials showed difficulty with administering adjuvant chemotherapy.
If you would elect for adjuvant therapy, which study helps guide your choice of regimen?
The upfront plan is to use a definitive radiation dose of 66 Gy. My reading supports the use of 5FU + cisplatin but another doctor is recommending FOL...
Liver and skeletal metastasis with no disease in the lung.
Preferred options in NCCN guidelines: 5FU+cisplatin, 5FU+oxaliplatin, paclitaxel+carboplatin?
In the case of multiple skip lesions in the thoracic esophagus and GE junction, the PTV may encompass nearly the entire esophagus, including the supra...
Do you utilize it immediately following chemoRT or wait until disease progression?
As a for instance, a centrally located primary tumor with mediastinal adenopathy that results in a TE fistula?
Currently we would recommend esophagea...
What chemotherapy and radiation doses/fractionation would you use once the airway has been stabilized to provide reasonably safe and effective palliat...
If the patient has large, bulky nodes would you consider starting after chemotherapy for cytoreduction? Or otherwise consider replanning mid-treatment...
If so, what regimen would you consider?
What other molecular tests do you routinely order on such tumors?
I.e. Would you treat most of the normal esophagus to include a mediastinal lymph node?
What regional lymph nodes do you include perigastric, portahepatic, periesophageal, celiac, splenic, pancreaticoduodenal, sup. mesenteric, paraesophag...
We use PET for esophageal, but not gastric cancer. GE junction seems like a grey area.
Does the advent of FLOT in gastric cancers, change your approach to GE adeno's? Would anyone consider FLOT followed by chemoradition followed by surge...
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Papers discussed in this category
The New England journal of medicine, 2001-09-06
J. Clin. Oncol., 2009-02-20
International journal of radiation oncology, biology, physics, 2007-02-01
Lancet Oncol., 2015-09-01
JAMA oncology, 2018-01-01
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006-03
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-03-01
J Clin Oncol, 2007 Apr 1
J Clin Oncol, 2005 Apr 1
Current oncology reports, 2019-04-04
Int. J. Radiat. Oncol. Biol. Phys., 2016 Sep 03
Int. J. Radiat. Oncol. Biol. Phys., 2017 Jan 09
Dis. Esophagus,
International journal of radiation oncology, biology, physics, 2015-07-15
JAMA, 1999-05-05
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-07-01
J. Clin. Oncol., 2016-08-10
Lancet Oncol., 2014-07-01
Ann. Oncol., 2014-07-01
J. Clin. Oncol., 2015-10-01
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-12-10
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-03-20
J. Clin. Oncol.,
N Engl J Med, 2007 Aug 16
The New England journal of medicine, 1999-08-12
Cancer, 2012-06-01
N. Engl. J. Med., 2012-05-31
Int. J. Radiat. Oncol. Biol. Phys., 2008 Jan 30
Thorac Surg Clin,
Lancet Oncol., 2014 Feb 18
The New England journal of medicine, 2018-12-06
Lancet, 2019 Oct 04
Pancreas,
Lancet, 2019 Apr 11