What is the current paradigm for breast cancer diagnosed with isolated metastases prior to initial treatment?

Topics: Breast Cancer • Radiation Oncology • Medical Oncology • Breast Cancer, Metastatic

Is there a role for loco-regional treatment in this scenario?

If a young patient with ER/PR positive cT2N2M1 IDC presents with a single bone metastasis in the hip, would this patient get comprehensive treatment with chemo, surgery, radiation to breast/chest wall/nodes, and SBRT to the hip?

Or, alternatively, would this be managed purely with systemic treatment with surgery/RT for palliation?

Answer from: Radiation Oncologist at Academic Institution

Surgery of the primary did not significantly improve overall survival in which patients were randomly allocated to receive systemic therapy alone or (for responding patients) to systemic therapy followed by primary tumor resection in the trial conducted by ECOG-ACRIN (Khan et al., PMID 34995128), at...

Comments

Radiation Oncologist at Lake Huron Medical Center
Terrifically comprehensive interpretation of all c...

Radiation Oncologist at Kaiser Permanente, Los Angeles Med Center
Dear Dr. @Recht, thank you very much for that exce...

Radiation Oncologist at Beth Israel Deaconess Medical Center
Dear Dr. @Girvigian, thank you for your kind words...

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