What is the current paradigm for breast cancer diagnosed with isolated metastases prior to initial treatment?
Is there a role for loco-regional treatment in this scenario?
If a young patient with ER/PR positive cT2N2M1 IDC presents with a single bone metastasis in the hip, would this patient get comprehensive treatment with chemo, surgery, radiation to breast/chest wall/nodes, and SBRT to the hip?
Or, alternatively, would this be managed purely with systemic treatment with surgery/RT for palliation?
1 Answer
Mednet MemberInvited Expert
Radiation Oncology · Beth Israel Deaconess Medical Center
Answered on
Surgery of the primary did not significantly improve overall survival in which patients were randomly allocated to receive systemic therapy alone or (for responding patients) to systemic therapy followed by primary tumor resection in the trial conducted by ECOG-ACRIN (Khan et al., PMID 34995128), at...
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